Madison Michael, MD, a neurosurgeon with Methodist University Hospital Neuroscience Institute and Semmes-Murphey Neurological and Spine Institute and assistant professor at the University of Tennessee Health Science Center, is helping to lead several clinical trials at Methodist University Hospital. The studies involve different experimental protocols for the treatment of gliomas, primary brain tumors, and genomic profiling of brain tumors and lumbar discs.

“Looking at the genomic studies of intracranial tumors, certain tumors, even though they carry the same name, differ substantially in their behavior,” said Dr. Michael. “For example, in one patient we will watch a tumor sit inactive for years showing no signs of growth in follow-up exams. We will see the exact same type of tumor grow rapidly in another patient.”

In collaboration with the University of Tennessee Department of Neurosurgery’s Molecular Neurosurgery research program, Dr. Michael and his research team is now using an approach known as genomic profiling which involves a tissue-based study to identify genes active in a given tumor.

“We are using genomic profiling to hopefully clarify the different ways tumors behavior even though they look the same under the microscope,” explained Dr. Michael. “Also, genomic profiling may enable us to individualize our therapies by knowing which ones may respond to certain drugs or which ones would be suited for radiation treatments. If we can gain insight into the behavior of the tumor, if we can determine which tumors will respond to certain treatments, we can hopefully optimize treatment to effectively eradicate the tumor.”

Dr. Michael says the size of the neuroscience program at Methodist University Hospital Neuroscience Institute makes it an ideal facility for research. So far in 2007, there have been over 1400 neuro surgeries performed which provides a large number of candidates for various clinical trials. The Institute, in collaboration with the University of Tennessee Health Science Center, provides academic and clinical services that are comprehensive, interdisciplinary, and supported by the latest technology. The institute consists of three basic components: neuroscience clinical programs, centers and services; neuroscience medical education and neurological research.

“Research is an exciting field,” said Dr. Michael. “I am always interested in translational research in which we take our findings and apply them to clinical treatments. Depending on the results, you can really change how certain diseases or conditions are treated and truly improve patient care.”

Dr. Michael is very excited about the potential of these studies to improve the treatment of common neurosurgical disorders.